The "Canker" quest forms part of an early-game side quest chain in *Kingdom Come: Deliverance 2*, requiring completion of "The Jaunt" first. This mission provides useful rewards like a mace or extra Groschen. Here's a complete walkthrough.
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Pick Up the Canker Side Quest

To begin "Canker," speak with Gules in Semine. The quest becomes available early when Gules is patrolling, though many players conveniently pick it up during Lord Semine and Agnes's wedding preparations. When interacting with Gules, inquire about his former bandit associates and volunteer to help eliminate them - Canker being your initial target.
Find and Kill Canker

Upon accepting the quest, your map highlights Canker's hideout north of Nebakov Mill. Approach cautiously - bandits frequently ambush travelers along this route. You have multiple options: stealthily bypass them, engage in combat, or simply flee. While random bandits pose minimal threat, unnecessary battles may leave you weakened before facing Canker.
The hidden bandit camp sits nestled within mountainous terrain, accessible through a narrow passage reminiscent of the Hermit's residence location from "Wedding Crashers." Prepare adequately before entering, as you'll confront Canker alongside several bandits.
Combat strategy varies - some bandits may flee depending on whom you attack first. However, expect to eliminate most enemies. Crucially, Canker remains committed to fighting, guaranteeing your opportunity to complete this quest objective.
Finish the Quest and Return to Gules
After defeating Canker and his cohorts, loot the Light Mace from his corpse as proof of completion (additional loot is yours for the taking). Return this item to Gules to conclude the quest.
Completion triggers a 24-hour in-game cooldown before Gules offers his next bandit elimination quest, "Handsome Charlie."